The main research question in my sampling and systematic retrospective review dissertation aimed to summarize the systemic, organizational, and interactional success determinants reported by primary care and public health collaborations in the United States. The study ultimately summarized 57 published case reports in 45 states. In terms of study design, this research project employed the methodological and contextual concepts of qualitative design, retrospective review, content analysis, data extraction, codebook development, coding extracted units of meaning, and operationalization of key terms. Creation of a credible manuscript began with an in-depth investigation of the essential elements of qualitative study design. This case reveals elements of the research process while highlighting research practicalities and lessons learned for future researchers.