This case is devoted to multitasking (performing two or more simultaneous tasks) in the face of task-irrelevant interruptions. I first briefly present how multitasking performance is typically measured in an experimental setting and introduce dual-tasking and task-switching paradigms. Next, I present how handling interruptions is measured in laboratory experiments. Finally, I present two experimental methods that combine both multitasking and dealing with interruptions. I focus on task-irrelevant interruptions, which are differentiated from task-relevant interruptions. I also show that ignoring interruptions might lead to better multitasking performance, especially when task-irrelevant interruptions are involved. Possible method modifications for future studies are discussed.