Women who have inappropriate gestational weight gain as well as women who begin pregnancy obese are at increased risk of adverse pregnancy, delivery, and birth outcomes. Excessive gestational weight gain and maternal obesity also are associated with increased risks of postnatal weight retention and long-term obesity in mothers and greater risk of obesity in children. In addition, feeding and activity habits established early in life can substantially affect the development of obesity in children. Given the importance of maternal health during gestation and the early postnatal period, Delta Healthy Sprouts was designed to test the comparative effectiveness of two treatments on appropriate gestational weight gain, postnatal weight control, and infant weight gain. This case study describes the development of this project from the identification of the research problem and formulation of the research hypotheses, the selection of a research design, the intervention delivery, the mechanics of primary data collection, and the challenges encountered along the way.