Small island states have need for high-quality research that is relevant to their context and peculiar cultures just as do larger constituencies. They are, however, faced with the challenge of severely reduced resources, both monetary and in the form of expertise. Integrity of the data collection process, even if disjointed, can be maintained by use of well-written protocols, by training and establishment of good interobserver reliabilities. Academic isolation can exacerbate the challenge of completing studies in these settings and may be addressed by cogent use of technology and well-conducted meetings. Other approaches include formal collaborations with experts outside of one’s specific discipline. This can lead to application of innovative techniques not in traditional use. This case study highlights methods that were used to overcome some of the challenges in mapping baseline nutrition-related childhood chronic disease risk profiles in a small island state.