This case study provides an overview of a research study with adolescents experiencing maternal cancer. It explores the methodological successes and limitations to promote a critical understanding of carrying out sensitive topic research with adolescents online and face to face. The study had a mixed-methods design, including both quantitative and qualitative data collection methodologies. The suitability of these methods for the research objectives is described. Further reflection around the ethical and methodological implications of carrying out participatory research with adolescents through challenging circumstances and experiences that may increase their vulnerability is provided.