This research project case focuses on designing an evidence-based intervention that could improve understanding of patients with multiple sclerosis about treatment risks and benefits. The case provides an overview of multiple sclerosis and the kinds of treatments that patients may take when they are diagnosed with this condition. The background of this research also explores why understanding treatment information is important. We then discuss how we employ different methodologies to ensure that we develop an effective evidence-based intervention for patients, namely, systematic reviews, surveys, experiments, and a crossover randomized controlled trial. As our research project is conducted with a patient population, this research case also explores the challenges faced while conducting research with patients.