Educators share the goals of closing achievement gaps and improving academic outcomes. Research conducted in a classroom setting may help identify problematic content and serve as a guide for implementing more effective and appropriate pedagogy. In addition, employing students to help instructors coordinate these studies can also serve as a learning experience for developing researchers. By examining a growth mind-set intervention that was recently implemented in a graduate-level biostatistics course, this case study highlights strategies and challenges associated with conducting research in a classroom and merging research with teaching. Study development, research considerations, lessons learned, and study limitations are discussed in depth to provide a resource for undergraduate and graduate students interested in learning about the use of in-class interventions in research methodology.