The provision of appropriate information is a key component of quality health care. This research project explored the role of accessible information in supporting the health and well-being of people with a learning disability. The project used mixed methods and random sampling. A total of 102 National Health Service clinicians completed an online questionnaire examining the nature, range, and their involvement in production of accessible information and was quantitatively analyzed. A total of 35 clinicians participated in focus group discussions; and 10 people with learning disabilities and 10 carers were interviewed. Focus groups and semi-structured interviews tapped information-seeking behavior and the use of accessible information to support inclusion and health-care decision making and were thematically analyzed, informed by a framework approach. The results from the questionnaire demonstrated variable use and understanding of accessible information, as well as correlations between knowledge of accessible information and views regarding its relevance. Qualitative data from the focus groups and interviews highlighted the crucial role of effective verbal engagement when using accessible information and the deficits in current National Health Service information provision. Our results highlight the potential of accessible information to support empowering partnerships with service users and thereby help address persistent health inequalities. The project illustrated the benefits of combining multiple perspectives, in terms of design, methodology, and analysis, and the need to make the research process as accessible as possible to promote the inclusion of all relevant stakeholders.