Methamphetamine has been perceived as a ‘white drug’ by those who study meth and by those who use it, although few researchers have explored the reasons. We conducted in-depth interviews with 17 White and 13 Black women at a women’s halfway house to learn more about how and why women begin using meth and how race influences their decisions and beliefs. We have summarized here the methodological strategies used for our qualitative research project. We cover the challenges faced and decisions made in gaining entrée into the facility, soliciting volunteers, designing a proper interview guide, determining proper interview logistics, analyzing transcripts, and choosing follow-up studies. We describe the need to make standing decisions about the research process before interviewing, and emphasize our use of open-ended and follow-up questions to let the interviewees shape the research process and follow-up studies.