This case study reflects on cross-disciplinary, health, and education PhD research that explored the educational experiences of children and young people with the medical condition cystic fibrosis. Children with medical conditions may experience particular difficulties in education, potentially making them vulnerable at school. During the case study, I discuss how I involved children with cystic fibrosis in the research. As a researcher who also has cystic fibrosis, I knew I would be unable to physically meet with children face-to-face due to the risk of cross-infection. This issue greatly influenced the methodological decisions taken throughout the study and ultimately led me to develop an innovate approach that would allow me to gain children’s perspectives. While the study essentially employed a mixed-methods approach, particular attention is paid to the use of online interviews, a method less frequently considered for research with children. The online interviews eliminated the risk of cross-infection, yet they were not without challenges. This case highlights some of the practical and methodological problems that were encountered through seeking the perspectives of children with cystic fibrosis in the research.