This case study describes a program of research that developed a new measure—the Adaptability Scale—and then tested this new measure through a set of substantive research questions and publications. Three phases of this research program are detailed: a measurement phase, a modeling phase, and a mediation phase. The aim of this case study is to demonstrate a systematic program of research that began with construct definition, construct development and measurement of adaptability (the measurement phase), explored predictors and consequences of adaptability (the modeling phase), and then more closely examined factors that may mediate the effects of adaptability (the mediation phase). Collectively, these three phases traverse the range and scope of a large survey-based research program, including some of the logistic and conceptual challenges and opportunities inherent in such a process. In exploring this research program, the case study gives due consideration to the relevant statistical procedures (e.g. confirmatory factor analysis, structural equation modeling) and the relevant research designs (e.g. cross-sectional and longitudinal correlational) that formed the fabric of data collection and data analysis.