Partially Randomized Preference Trial Design

Partially randomized preference trials (PRPTs), using Brewin and Bradley's design, are a product of combining the best elements of randomized controlled trials (RCTs), which involve random allocation of different treatments to willing patients, and feasibility studies, in which patients choose their preferred treatment. PRPTs give patients, who are recruited into a clinical trial, the option to choose their preferred method of treatment, and if the patients have no strong motivation toward a specific treatment, they are asked if they will agree to random allocation to one or another treatment method. All patients recruited into the PRPT need to be given clear, accurate, and detailed information about what the treatments to be offered in the trial involve. They can then make an informed decision when given ...